Among various attempts to create international associations integrating the countries of the South, two cases: Association of Southeast Asian Nations and Mercado Comun del Cono Sur deserve particular attention. Not because of their, rather modest, achievements, but due to the institutional characteristics, economic, political and cultural ambitions and the determination to search for original ways of development. ASEAN and MERCOSUR countries are ready to cooperate with the important global partners but, at the same time, have their own, independent views on many issues, in which in other circumstances, they would rather do easy concessions in favour of the powerful global organizations and countries.