The paper aims to discuss the major trends in changes of regional differences of economic wellbeing and the resulting spatial mobility of population as well as some regional consequences of these processes. The research is based on an empirical methodology, and visual analysis of mapped data is the main research method. Since the collapse of the Soviet Union, fast decrease of employment in industry and agriculture has damaged, first of all, peripheral regions and, later, resulted in mass emigration, which is still evident in most Lithuanian municipalities. The decrease of the number of jobs in these sectors and its increase in those located in different places meant that most residents of non-metropolitan regions had to find new jobs outside the localities in which they resided. This resulted in growing mobility of the population, expressed by growing foreign emigration, inner migrations, and commuting, which continue to shape the social structure of the country to the present day, as spatial structures change more slowly than modes of production. Differences in wellbeing, which appeared at the end of the 20th century, played a role in accelerating emigration processes, which are still damaging local labour supply and economic development in many regions.