The paper uses the advanced spatial shift-share method to examine the tendency of some occupational diseases to occur in particular regions and sectors of the economy. The analysis, conducted in the years 2003–2010, concerned groups of diseases, and was based on regional data on occupational disease incidence in Poland according to disease groups. The analyzed variables were relative increments (of rates of changes) of the number of diagnosed occupational diseases, whereas the reference variable was the share of the diagnosed occupational diseases (in particular regions and groups of diseases) in the general number of diagnosed occupational diseases in the country (regional weights). The results of that research were then used to compare classical and non-classical methods of shift-share analysis.