Career paths of modern politicians have increasingly become diversified and drifter away from the classical hierarchical career pattern. The article addresses new theoretical concepts and empirical studies, which have been developed since the beginning of the 21st century by the multilevel government school (MLG) in relation to the careers of regional politicians and new career paths in general. As being a regional politician has become a profession, the investigation of the MLG school focuses on the political careers of such politicians, and most of all reflects the transformation of modern states as a result of regionalization and development of supranational European institutions. As a central theoretical contribution of the MLG school, Bochert’s “Conceptual Approach to Political Careers in Multilevel Systems” is discussed as the most comprehensive and advanced model of addressing the impact of the institutional setting on Carter opportunities. The final part of the article presents an overview of MLG research, which has led to a recognition of new types of political careers.